... greatly throughout development and in response to specific environmental cues. The import process is, therefore, tightly regulated, and it has emerged that the ubiquitin-proteasome system (UPS) plays a key role in this regard, acting at several different steps in the process. The UPS is involved...

... (ubiquitin–proteasome system) with the OMM. In yeast, Vms1 [VCP (valosin-containing protein) (p97)/Cdc48-associated mitochondrial-stress-responsive 1] protein recruits Cdc48/p97 to the OMM. In mammalian systems, the E3 ubiquitin ligase parkin regulates the recruitment of Cdc48/p97 to mitochondria, subsequent...

... role of this Dub in the pathway. comparative proteomics cytokine deubiquitinating enzyme signalling ubiquitin–proteasome system The ubiquitin–proteasome system has built a complex network of signals based on the diversity of ubiquitin linkages and their specific recognition. One...

...Ulrike Seifert; Elke Krüger Peptide generation by the UPS (ubiquitin–proteasome system) is rate-limiting in MHC class I-restricted antigen presentation in response to virus-induced IFNs (interferons). In this process, the role of IFN-induced rapid remodelling of the UPS is less defined. IFN...

... PrP Sc infections scrapie form of PrP UPS ubiquitin–proteasome system Our studies on yeast prion formation were funded by the BBSRC (Biotechnology and Biological Sciences Research Council) and the Wellcome Trust. References 1 Griffith J.S. Self-replication and scrapie...

... Biochemical Society 2008 autophagy cytosol proteasome protein degradation tripeptidyl peptidase II (TPPII) ubiquitin–proteasome system It is a well-established fact that the proteasome is the main culprit for protein turnover in the nucleus and the cytosol. The proteasome is a large...

... proteins and the sequestration of components of the UPS (ubiquitin–proteasome system). Unfortunately, as we age, the efficiency of the UPS declines, suggesting that the presence of ubiquitinated proteins and UPS components in inclusions may reflect unsuccessful attempts by the (failing) UPS to remove...

...J.P. Chapple; J. van der Spuy; S. Poopalasundaram; M.E. Cheetham The heat-shock protein 70 chaperone machine is functionally connected to the ubiquitin–proteasome system by the co-chaperone CHIP. In this article, we discuss evidence that the neuronal DnaJ proteins HSJ1a and HSJ1b may represent...