... agreement with JISC. DNA damage response DNA synthesis and repair genome integrity post translational modification SUMOylation ubiquitin signalling SUMOylation is a protein post-translational modification whereby SUMOs are covalently attached to target lysine residues. Mature SUMO2...

... enzymes protein degradation ubiquitin ubiquitin chains ubiquitin signalling Figure 1. Overview of chain initiating and chain elongating E2 enzymes. ( A ) E2 enzymes are charged with ubiquitin by a ubiquitin activating E1 enzyme. The resulting E2∼Ub conjugate is usually activated...

..., specific substrates or specific conditions, may entail various permutations of the ubiquitin signal. For instance, Lysine11- and Lysine29-linked polyubiquitin linkages were also found to accumulate upon proteasome inhibition and probably serve in secondary chain types for targeting to proteasomes [ 44–47...

...-Lafoz , M. , Chandra , M. et al. ( 2016 ) A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex . Nat. Struct. Mol. Biol. 23 , 921 – 932 10.1038/nsmb.3290 endosomal sorting endosome microfilaments ubiquitin signalling...

... of Walter and Eliza Hall Institute in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. enzyme activity post-translational modification RBR ubiquitin ligases ubiquitin ligases ubiquitin signalling...

... by a combination of polyubiquitin chain length, linkage type, numbers of ubiquitin chains per target, and decoration of ubiquitin with other small modifiers. However, many questions remain about how different ubiquitin signals are specifically recognised and transduced by the decoding ubiquitin-binding domains...

... ubiquitin signalling RING dimerisation appears to be a requirement for TRIM E3 catalytic activity, and recent biochemical and biophysical studies on three different TRIM ligases (TRIM5α, 25 and 32) have suggested three different mechanisms how this might be achieved [ 24 – 26 ]. TRIM5α...

... with knowledge of other ubiquitin signals, the Met1 signal is unique in that the enzymes responsible for the assembly, recognition, and disassembly are known. The following sections describe the molecular details for how each of these components achieves specificity towards regulating the Met1 signal...