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Keyword: vascular endothelial growth factor (VEGF)
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Articles
Biochem Soc Trans (2014) 42 (6): 1569-1575.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) A high level of vascularization was observed in human tumours more than a century ago and the hypothesis that tumours release growth factors to...
Articles
Biochem Soc Trans (2014) 42 (6): 1601-1607.
Published: 17 November 2014
... angiogenesis or compromising the function or stability of pre-existing tumour blood vessels. The vascular endothelial growth factor (VEGF) signalling axis remains the most widely studied, with biological and small-molecule therapeutics now registered for clinical use. However, despite these successes, the...
Articles
Biochem Soc Trans (2014) 42 (6): 1576-1583.
Published: 17 November 2014
... cells and, hence, suitable for targeting of the vasculature. Both genetic and drug targeting experiments have demonstrated the requirement for the vascular endothelial growth factor (VEGF) system, the Delta-like–Notch system and the transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP...
Articles
Biochem Soc Trans (2014) 42 (6): 1616-1622.
Published: 17 November 2014
... Society 2014 muscle contraction shear stress skeletal muscle stretch vascular endothelial growth factor (VEGF) Skeletal muscle tissue is highly dependent on an adequate supply of oxygen for energy production. At rest, oxygen uptake by the muscle is approximately 1 ml of oxygen/min per...
Articles
Biochem Soc Trans (2012) 40 (4): 831-835.
Published: 20 July 2012
... serine–arginine protein kinase 1 (SRPK1) serine/arginine-rich splicing factor 1 (SRSF1) vascular endothelial growth factor (VEGF) SRPK1 was first described in 1994 following the isolation of proteins that bind phosphorylated SR splicing factors in mitotic HeLa cells extracts [ 1 ]. SR proteins...
Articles
Biochem Soc Trans (2012) 40 (1): 20-25.
Published: 19 January 2012
... Dortmund, Germany (email Sina.Koch@mpi-dortmund.mpg.de ). 4 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis anti-VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor (VEGF) The mammalian...
Articles
Biochem Soc Trans (2011) 39 (6): 1551-1555.
Published: 21 November 2011
... angiogenesis pre-eclampsia signalling tissue remodelling vascular endothelial growth factor (VEGF) The plenary lecture was delivered by Peter Wagner [ 1 ] on the critical role of arguably the most well-known and significant player in angiogenesis, VEGF (vascular endothelial growth factor). This...
Articles
Biochem Soc Trans (2011) 39 (6): 1654-1658.
Published: 21 November 2011
... correspondence should be addressed (email abanfi@uhbs.ch ). 14 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiopoietin neuropilin-1 platelet-derived growth factor BB (PDGF-BB) transforming growth factor β (TGFβ) vascular endothelial growth factor (VEGF...
Articles
Biochem Soc Trans (2011) 39 (6): 1583-1591.
Published: 21 November 2011
... vascular endothelial growth factor (VEGF) NRP (neuropilin) 1 and the related molecule NRP2 are receptors for two unrelated types of polypeptide ligand: class 3 semaphorins, a subtype of a large family of secreted polypeptides essential mainly for targeting neurons to their destination tissues in...
Articles
Biochem Soc Trans (2011) 39 (6): 1619-1627.
Published: 21 November 2011
..., distribution and reproduction in any medium, provided the original work is properly cited. cytokine inflammation pre-eclampsia soluble endoglin (sEng) soluble Fms-like tyrosine kinase receptor-1 (sFlt-1) vascular endothelial growth factor (VEGF) Pre-eclampsia is an important cause of...
Articles
Biochem Soc Trans (2011) 39 (6): 1556-1559.
Published: 21 November 2011
... hypoxia-inducible factor (HIF) inflammation vascular endothelial growth factor (VEGF) In 1979, Dvorak et al. [ 1 ] reported the discovery of a new molecule they called VPF (vascular permeability factor). It was later renamed VEGF (vascular endothelial growth factor) [ 2 ]. This molecule became...
Articles
Biochem Soc Trans (2011) 39 (6): 1560-1564.
Published: 21 November 2011
... correspondence should be addressed (email a.bikfalvi@angio.u-bordeaux1.fr ). 12 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis chemokine combinatorial therapy resistance to anti-angiogenesis therapy stress response vascular endothelial growth...
Articles
Biochem Soc Trans (2011) 39 (6): 1565-1570.
Published: 21 November 2011
... email c.a.staton@shef.ac.uk 6 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis class 3 semaphorin neuropilin plexin vascular endothelial growth factor (VEGF) There are eight different classes of semaphorins, of which five classes are...
Articles
Biochem Soc Trans (2011) 39 (6): 1644-1648.
Published: 21 November 2011
... sprouting vascular endothelial growth factor (VEGF) VEGF (vascular endothelial growth factor-A) is the master regulator of angiogenesis both in physiological development and in disease [ 1 ] and is capable of starting the complex cascade of events leading to endothelial cell activation, assembly of...
Articles
Biochem Soc Trans (2011) 39 (6): 1649-1653.
Published: 21 November 2011
... chemokine endothelial cell regulated upon activation normal T-cell expressed and secreted (RANTES) vascular endothelial growth factor (VEGF) A vessel wall is composed of an endothelial cells monolayer (intima), lining the lumen of the artery and directly in contact with the circulating blood...
Articles
Biochem Soc Trans (2011) 39 (6): 1576-1582.
Published: 21 November 2011
... activation, and potentially some symptoms, of pre-eclampsia. 1 email Dave.Bates@bristol.ac.uk 19 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 placental growth factor (PlGF) pre-eclampsia vascular endothelial growth factor (VEGF) Pre-eclampsia...
Articles
Biochem Soc Trans (2009) 37 (6): 1184-1188.
Published: 19 November 2009
... pathways to cellular events. 1 To whom correspondence should be addressed (email h.mellor@bristol.ac.uk ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...
Articles
Biochem Soc Trans (2009) 37 (6): 1237-1242.
Published: 19 November 2009
... © 2009 Biochemical Society 2009 carbon monoxide haem oxygenase-1 (HO-1) pre-eclampsia soluble endoglin (sEng) soluble Fms-like tyrosine kinase-1 (sFlt-1) vascular endothelial growth factor (VEGF) Pre-eclampsia is a pregnancy-specific multi-organ syndrome characterized by widespread...
Articles
Biochem Soc Trans (2009) 37 (6): 1161-1166.
Published: 19 November 2009
... shibuya@ims.u-tokyo.ac.jp 28 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenic therapy oedema vascular endothelial growth factor (VEGF) vascular endothelial growth factor E (VEGF-E) vascular endothelial growth factor receptor 1 (VEGFR-1...
Articles
Biochem Soc Trans (2009) 37 (6): 1228-1232.
Published: 19 November 2009
... diverse ligands, the class 3 semaphorin SEMA3A and an isoform of the vascular endothelial growth factor VEGF-A termed VEGF 165 (VEGF 164 in mice). In vitro , SEMA3A competes with VEGF 164 for binding to NRP1 to modulate the migration of endothelial cells and neuronal progenitors. It was therefore...
Articles
Biochem Soc Trans (2009) 37 (6): 1171-1178.
Published: 19 November 2009
... partners. 1 To whom correspondence should be addressed (email i.zachary@ucl.ac.uk ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1) and the...
Articles
Biochem Soc Trans (2009) 37 (6): 1193-1197.
Published: 19 November 2009
... tyrosine kinase signalling vascular endothelial growth factor (VEGF) The vascular endothelium employs two cell-surface RTKs (receptor tyrosine kinases), VEGFR [VEGF (vascular endothelial growth factor) receptor] 1/Flt-1 (Fms-like tyrosine kinase 1) and VEGFR2/KDR (kinase insert domain receptor...
Articles
Biochem Soc Trans (2009) 37 (6): 1167-1170.
Published: 19 November 2009
... basis of VEGF resistance in diabetes mellitus. 1 email j.waltenberger@mumc.nl 7 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis diabetes mellitus endothelial dysfunction signal transduction vascular endothelial growth...
Articles
Biochem Soc Trans (2009) 37 (6): 1198-1200.
Published: 19 November 2009
... angiogenesis arteriogenesis gene therapy ischaemia lymphangiogenesis vascular endothelial growth factor (VEGF) Therapeutic angiogenesis involves stimulation of angiogenesis, arteriogenesis and lymphangiogenesis [ 1 ]. Angiogenesis means sprouting, bridging, intussusception or enlargement of...
Articles
Biochem Soc Trans (2009) 37 (6): 1221-1227.
Published: 19 November 2009
... compilation © 2009 Biochemical Society 2009 hypoxia ischaemic disease Notch intracellular domain Notch signalling therapeutic angiogenesis vascular endothelial growth factor (VEGF) In the Western world, ischaemic disease is highly prevalent and is associated with elevated morbidity and...
Articles
Biochem Soc Trans (2009) 37 (4): 805-810.
Published: 22 July 2009
... endothelial progenitor cell (EPC) inflammation lung vascular endothelial growth factor (VEGF) The human lung circulation consists of two blood supply systems: a bronchial vasculature that is the systemic arterial blood supply providing oxygenated blood and nutrients to the lung tissue and a...
Articles
Biochem Soc Trans (2008) 36 (5): 946-949.
Published: 19 September 2008
... transforming growth factor-β1 (TGF-β1) vascular endothelial growth factor (VEGF) Hypertension is an important contributor to diabetic renal disease, and the interplay between hypertension and renal disease is complex [ 1 , 2 ]: renal impairment contributes to the development and severity of...
Articles
Biochem Soc Trans (2007) 35 (4): 701-703.
Published: 20 July 2007
... cathepsin K prostate cancer secreted protein acidic and rich in cysteine (SPARC) vascular endothelial growth factor (VEGF) Skeletal metastasis is the result of interaction of the tumour cells with the bone microenvironment and requires processes such as proteolytic degradation and osteoclastic...
Articles
Biochem Soc Trans (2006) 34 (3): 451-453.
Published: 22 May 2006
... receptors, extracellular matrix molecules and enzymes bind to specific sites on the HS sugar chain. For example, HS proteoglycans have profound effects on the bioactivity of the key angiogenic factor VEGF (vascular endothelial growth factor) (VEGF 165 ), affecting its diffusion, half-life and interaction...
Articles
Biochem Soc Trans (2003) 31 (6): 1171-1177.
Published: 01 December 2003
... Essex, Colchester, 2–4 July 2003 10 June 2003 © 2003 Biochemical Society 2003 angiogenesis Flt1 kinase-insert-domain-containing receptor (KDR) mitogen-activated protein kinase (MAPK) survival vascular endothelial growth factor (VEGF) Abbreviations used: eNOS...