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Keywords: vascular endothelial growth factor (VEGF)
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Articles
Exploring the role of endothelium in the tumour response to anti-angiogenic therapy
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1569–1575.
Published: 17 November 2014
... ). 12 6 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) A high level of vascularization was observed in human tumours more than a century ago...
Articles
Mechanisms that influence tumour response to VEGF-pathway inhibitors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1601–1607.
Published: 17 November 2014
... or stability of pre-existing tumour blood vessels. The vascular endothelial growth factor (VEGF) signalling axis remains the most widely studied, with biological and small-molecule therapeutics now registered for clinical use. However, despite these successes, the activity of these agents is not as widespread...
Articles
VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1576–1583.
Published: 17 November 2014
... cells and, hence, suitable for targeting of the vasculature. Both genetic and drug targeting experiments have demonstrated the requirement for the vascular endothelial growth factor (VEGF) system, the Delta-like–Notch system and the transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP...
Articles
Capillary growth in human skeletal muscle: physiological factors and the balance between pro-angiogenic and angiostatic factors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1616–1622.
Published: 17 November 2014
... muscle contraction shear stress skeletal muscle stretch vascular endothelial growth factor (VEGF) In a large number of animal studies, the effect of mechanically induced signals on capillary growth has been examined. Primarily two models have been used: surgical extirpation for the examination...
Articles
SRPK1 inhibition in vivo : modulation of VEGF splicing and potential treatment for multiple diseases
Available to PurchaseSebastian Oltean, Melissa Gammons, Richard Hulse, Maryam Hamdollah-Zadeh, Athina Mavrou, Lucy Donaldson, Andrew H. Salmon, Steve J. Harper, Michael R. Ladomery, David O. Bates
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 831–835.
Published: 20 July 2012
... serine–arginine protein kinase 1 (SRPK1) serine/arginine-rich splicing factor 1 (SRSF1) vascular endothelial growth factor (VEGF) Figure 1 Inhibition of SRPK1 as a potential treatment in several disease states SRPIN340 inhibition of SRPK1 results in hypophosphorylation of the splicing factor...
Articles
Neuropilin signalling in angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 20–25.
Published: 19 January 2012
... 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis anti-VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor (VEGF) The mammalian VEGF (vascular endothelial growth factor) family consists...
Articles
Advances in the Cellular and Molecular Biology of Angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1551–1555.
Published: 21 November 2011
... or dysfunction in human diseases, and application of these findings towards translational medicine. © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis pre-eclampsia signalling tissue remodelling vascular endothelial growth factor (VEGF) 1 Correspondence may...
Articles
Taming of the wild vessel: promoting vessel stabilization for safe therapeutic angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1654–1658.
Published: 21 November 2011
... The Authors Journal compilation © 2011 Biochemical Society 2011 angiopoietin neuropilin-1 platelet-derived growth factor BB (PDGF-BB) transforming growth factor β (TGFβ) vascular endothelial growth factor (VEGF) vascular maturation Previous studies have revealed an intriguing role...
Articles
How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1583–1591.
Published: 21 November 2011
... or chemoattraction in VEGF-treated ECs [ 9 – 13 ]. angiogenesis endothelium neuropilin-1 platelet-derived growth factor (PDGF) receptor tyrosine kinase vascular endothelial growth factor (VEGF) NRP (neuropilin) 1 and the related molecule NRP2 are receptors for two unrelated types of polypeptide...
Articles
Is inflammation the cause of pre-eclampsia?
Open Access
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1619–1627.
Published: 21 November 2011
... inflammation pre-eclampsia soluble endoglin (sEng) soluble Fms-like tyrosine kinase receptor-1 (sFlt-1) vascular endothelial growth factor (VEGF) eNOS endothelial nitric oxide synthase ET-1 endothelin-1 HELLP haemolysis, elevated liver enzymes and low platelets IFNγ interferon...
Articles
The critical role of VEGF in skeletal muscle angiogenesis and blood flow
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
... growth factor (VEGF) In 1979, Dvorak et al. [ 1 ] reported the discovery of a new molecule they called VPF (vascular permeability factor). It was later renamed VEGF (vascular endothelial growth factor) [ 2 ]. This molecule became the subject of substantial interest as a major player...
Articles
Inhibition of angiogenesis and the angiogenesis/invasion shift
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1560–1564.
Published: 21 November 2011
... stress response vascular endothelial growth factor (VEGF) Angiogenesis inhibition has generated positive results in clinical trials in colon, kidney, lung and breast cancer. The discovery of a link between the VHL (von Hippel–Lindau) tumour-suppressor gene, HIF-1 (hypoxia-inducible factor 1...
Articles
Class 3 semaphorins and their receptors in physiological and pathological angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1565–1570.
Published: 21 November 2011
... on tumor vessels and tumor cells in solid malignancies BMC Cancer 2009 9 297 angiogenesis class 3 semaphorin neuropilin plexin vascular endothelial growth factor (VEGF) A solid tumour cannot progress without initiating angiogenesis and therefore it is unsurprising...
Articles
Angiogenic properties of the chemokine RANTES/CCL5
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1649–1653.
Published: 21 November 2011
... chemokine endothelial cell regulated upon activation normal T-cell expressed and secreted (RANTES) vascular endothelial growth factor (VEGF) The blood vessels and heart are the first organs to form and function during mammalian development, but the vasculature continues to remodel dynamically...
Articles
To sprout or to split? VEGF, Notch and vascular morphogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1644–1648.
Published: 21 November 2011
... of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat: angiogenesis and angioma formation J. Am. Coll. Cardiol. 2000 35 1323 1330 9 Gupta R. Tongers J. Losordo D.W. Human studies of angiogenic...
Articles
An unexpected tail of VEGF and PlGF in pre-eclampsia
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1576–1582.
Published: 21 November 2011
.... Circulating angiogenic factors and the risk of preeclampsia N. Engl. J. Med. 2004 350 672 683 9 Chung J.Y. Song Y. Wang Y. Magness R.R. Zheng J. Differential expression of vascular endothelial growth factor (VEGF), endocrine gland derived-VEGF, and VEGF receptors in human...
Articles
Neuropilin ligands in vascular and neuronal patterning
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1228–1232.
Published: 19 November 2009
... diverse ligands, the class 3 semaphorin SEMA3A and an isoform of the vascular endothelial growth factor VEGF-A termed VEGF 165 (VEGF 164 in mice). In vitro , SEMA3A competes with VEGF 164 for binding to NRP1 to modulate the migration of endothelial cells and neuronal progenitors. It was therefore...
Articles
The role of neuropilins in cell signalling
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1171–1178.
Published: 19 November 2009
... partners. 1 To whom correspondence should be addressed (email [email protected] ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1...
Articles
VEGF receptor trafficking in angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1184–1188.
Published: 19 November 2009
... pathways to cellular events. 1 To whom correspondence should be addressed (email [email protected] ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...
Articles
Gene therapy with vascular endothelial growth factors
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1198–1200.
Published: 19 November 2009
... angiogenesis arteriogenesis gene therapy ischaemia lymphangiogenesis vascular endothelial growth factor (VEGF) Therapeutic angiogenesis involves stimulation of angiogenesis, arteriogenesis and lymphangiogenesis [ 1 ]. Angiogenesis means sprouting, bridging, intussusception or enlargement...
Articles
Can the biology of VEGF and haem oxygenases help solve pre-eclampsia?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1237–1242.
Published: 19 November 2009
... [email protected] ). 7 7 2009 28 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 carbon monoxide haem oxygenase-1 (HO-1) pre-eclampsia soluble endoglin (sEng) soluble Fms-like tyrosine kinase-1 (sFlt-1) vascular endothelial growth factor (VEGF...
Articles
Unique signal transduction of the VEGF family members VEGF-A and VEGF-E
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1161–1166.
Published: 19 November 2009
... compilation © 2009 Biochemical Society 2009 angiogenic therapy oedema vascular endothelial growth factor (VEGF) vascular endothelial growth factor E (VEGF-E) vascular endothelial growth factor receptor 1 (VEGFR-1) Blood vessels supply nutrients and oxygen to tissues in the body...
Articles
VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1193–1197.
Published: 19 November 2009
... endocytosis proteolysis receptor tyrosine kinase signalling vascular endothelial growth factor (VEGF) The vascular endothelium employs two cell-surface RTKs (receptor tyrosine kinases), VEGFR [VEGF (vascular endothelial growth factor) receptor] 1/Flt-1 (Fms-like tyrosine kinase 1) and VEGFR2/KDR...
Articles
VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1167–1170.
Published: 19 November 2009
... basis of VEGF resistance in diabetes mellitus. 7 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis diabetes mellitus endothelial dysfunction signal transduction vascular endothelial growth factor (VEGF) 1 email...
Articles
Notch signalling in ischaemia-induced angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1221–1227.
Published: 19 November 2009
... intracellular domain Notch signalling therapeutic angiogenesis vascular endothelial growth factor (VEGF) In the Western world, ischaemic disease is highly prevalent and is associated with elevated morbidity and mortality. Critical limb ischaemia is the end-stage outcome of multiple types...
Articles
Angioplasticity in asthma
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 805–810.
Published: 22 July 2009
... endothelial progenitor cell (EPC) inflammation lung vascular endothelial growth factor (VEGF) The human lung circulation consists of two blood supply systems: a bronchial vasculature that is the systemic arterial blood supply providing oxygenated blood and nutrients to the lung tissue...
Articles
Molecular mechanisms of proteinuria in diabetes
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 946–949.
Published: 19 September 2008
... proteinuria transforming growth factor-β1 (TGF-β1) vascular endothelial growth factor (VEGF) Hypertension is an important contributor to diabetic renal disease, and the interplay between hypertension and renal disease is complex [ 1 , 2 ]: renal impairment contributes to the development and severity...
Articles
Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 701–703.
Published: 20 July 2007
... secreted protein acidic and rich in cysteine (SPARC) vascular endothelial growth factor (VEGF) Skeletal metastasis is the result of interaction of the tumour cells with the bone microenvironment and requires processes such as proteolytic degradation and osteoclastic bone resorption. The preferred...
Articles
The role of heparan sulphate proteoglycans in angiogenesis
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 451–453.
Published: 22 May 2006
... and their receptors, extracellular matrix molecules and enzymes bind to specific sites on the HS sugar chain. For example, HS proteoglycans have profound effects on the bioactivity of the key angiogenic factor VEGF (vascular endothelial growth factor) (VEGF 165 ), affecting its diffusion, half-life and interaction...
Articles
VEGF signalling: integration and multi-tasking in endothelial cell biology
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Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1171–1177.
Published: 01 December 2003
... of Essex, Colchester, 2–4 July 2003 10 June 2003 © 2003 Biochemical Society 2003 angiogenesis Flt1 kinase-insert-domain-containing receptor (KDR) mitogen-activated protein kinase (MAPK) survival vascular endothelial growth factor (VEGF) Abbreviations used: eNOS...
