...Matthew D. Worssam; Helle F. Jørgensen In contrast with the heart, the adult mammalian vasculature retains significant remodelling capacity, dysregulation of which is implicated in disease development. In particular, vascular smooth muscle cells (VSMCs) play major roles in the pathological vascular...

... vasoconstriction and vascular remodelling. Ion channels are key determinants of vascular smooth muscle tone and homeostasis, and four PAH channelopathies ( KCNK3 , ABCC8 , KCNA5 , TRPC6 ) have been identified so far. However, the contribution of ion channels in other forms of PAH, which account for the majority...

... 2021 cardiovascular disease microrna phenotype vascular smooth muscle miR-145 is embedded within this transcriptional network. SRF, myocardin and MRTF-A have all been demonstrated to promote expression of miR-145 in vascular SMC [ 5 , 10 ]. miR-145 itself directly targets KLF4 in human...

...Owain Llŷr Roberts; Caroline Dart The second messenger cAMP plays a central role in mediating vascular smooth muscle relaxation in response to vasoactive transmitters and in strengthening endothelial cell–cell junctions that regulate the movement of solutes, cells and macromolecules between...