The serum half-life of bovine [3H]acetyltrypsin was estimated to be 9 rain following intravenous administration in rats. This was maintained when six successive doses of 200 μg each were given at 1-h intervals. The enzyme was removed from the circulation after complexing with α2-macroglobulin (α2-M). The amount of3H label appearing in bile increased with each successive dose and this was associated with breakdown products (<10 000 daltons) of the α2-M/[3H] acetyltrypsin. Intact α-M/[3H] acetyltrypsin was recovered from bile but represented only 0.06% of the administered dose of active enzyme.
Research Article| October 01 1981
The biliary excretion of trypsin in rats
David A. W. Grant;
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David A. W. Grant, Simon C. Fleming; The biliary excretion of trypsin in rats. Biosci Rep 1 October 1981; 1 (10): 765–770. doi: https://doi.org/10.1007/BF01114798
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