The N-terminal amino acid sequence of human Cl̄s b chain has been extended to 52 residues. The histidine residue involved in the charge-relay system is located at position 38, whereas the ‘histidine-loop’ disulphide bridge is missing. So far, human complement subcomponents Cl̄s are the only known mammalian serine proteinases lacking this disulphide bridge.

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