Rats given an LD50 dose of Be2+ showed reduced activities of ornithine decarboxytase and tyrosine aminotransferase in liver in response to dexamethasone induction. Control fed animals showed ‘superinduction’. Be2+ also inhibited the uptake of [3H]orotic acid into rapidly labelled RNA of ribonucleoprotein particles extracted from liver nuclei in isomolar solutions at pH 8.0. Consistent with inhibition of cytoplasmic protein kinase reported previously (Kaser et at., 1980), the uptake of [32P]Pi into proteins in the ribonucleoprotein particles was also diminished.
Research Article| March 01 1981
Enzyme induction in rat liver: The effects of Be2+in vivo
Margery G. Ord;
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Margery G. Ord, Lloyd A. Stocken; Enzyme induction in rat liver: The effects of Be2+in vivo. Biosci Rep 1 March 1981; 1 (3): 217–222. doi: https://doi.org/10.1007/BF01114907
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