31P NMR now provides a totally non-invasive method of studying the metabolism of selected tissues and organs within whole animals and humans. A wide range of studies therefore becomes feasible. For example, there have been problems associated with metabolic studies of isolated organs such as the brain which are particularly sensitive to hypoxia; these problems can now be circumvented by studying the organ within the whole animal. Theories of metabolic control are based largely on studies performed in vitro, and it should now prove possible to test some of these theories directly in vivo. NMR could provide significant advances in our understanding of organ preservation and function. Finally,31P NMR provides a new method of studying the metabolic basis and effects of disease in humans and in animal models. The technique could also provide an objective way of assessing the effectiveness of procedures that are used in the treatment of human disease.
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Review Article|
June 01 1981
Metabolic studies of whole animals and humans using phosphorus nuclear magnetic resonance: Review
David G. Gadian
David G. Gadian
1Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.
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Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1981 The Biochemical Society
1981
Biosci Rep (1981) 1 (6): 449–460.
Citation
David G. Gadian; Metabolic studies of whole animals and humans using phosphorus nuclear magnetic resonance: Review. Biosci Rep 1 June 1981; 1 (6): 449–460. doi: https://doi.org/10.1007/BF01121578
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