Lipogenesis in livers of fed but not of starved rats is increased after intragastric feeding with glucose. In contrast, lipogenesis in brown adipose tissue increases in both fed and starved animals. These observations suggest that lipogenesis in brown adipose tissue is regulated by mechanisms in addition to, or other than, those operating in liver. The fate of newly synthesized lipid in brown adipose tissue is not known. However, the formation of palmitoyl-carnitine from palmitoyl-CoA and carnitine by mitochondria from brown fat was inhibited by malonyl-CoA. Although inhibition was not 100%, it is implied that mitochondrial uptake of the newly synthesized fat by the carnitine acyltransferase system is restricted under conditions of increased lipogenesis.
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Research Article| June 01 1981
Lipogenesis in response to an oral glucose load in fed and starved rats
Mary C. Sugden;
Mary C. Sugden
†Department of Biochemistry, Charing Cross Hospital Medical School, Fulham Palace Road, Hammersmith, London W6 8RF, U.K.
§Department of Surgery, Charing Cross Hospital Medical School, Fulham Palace Road, Hammersmith, London W6 8RF, U.K.
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David L. Watts;
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Mary C. Sugden, David L. Watts, Christopher E. Marshall; Lipogenesis in response to an oral glucose load in fed and starved rats. Biosci Rep 1 June 1981; 1 (6): 469–476. doi: https://doi.org/10.1007/BF01121580
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