A new interpretation of structure-function relationships in the insulin molecule is presented. Negative cooperativity is postulated to arise from a dimerization event occurring between two receptor-bound molecules. The receptor-binding surface of insulin can necessarily not involve residues involved in dimerization as has been generally accepted. Support for this interpretation is based on published data.
Research Article| June 01 1981
Structure-function relationships in insulin
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D. J. Saunders; Structure-function relationships in insulin. Biosci Rep 1 June 1981; 1 (6): 485–495. doi: https://doi.org/10.1007/BF01121582
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