Effects of somatostatin (SOM) on tissue contents of proteins, total lipids and phospholipids were investigated in regenerating and intact liver tissue of Y-59 rats. Whereas SOM inhibited protein accumulation in regenerating liver, the hormone evoked and increase in total lipids, and specially in phosphatidylcholine, phosphatidylethnolamine, phosphatidylserine (PS) and phosphatidylinositol (PI). Since the same effects were not seen when intact liver was analyzed, it is assumed that SOM acts primarily on tissue stimulated to rapid growth. The increase of PS+PI fractions indicates a specific effect of SOM on the metabolism of phosphatidylinositides. Such an effect might result from the interference of the hormone with the action of growth factors that accelerate phosphatidylinositol breakdown.
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February 01 1991
Somatostatin promotes accumulation of phospholipids in regenerating liver tissue of rats
Cedomila Milin;
Cedomila Milin
1Department of Chemistry and Biochemistry, University “Vladimir Bakaric” of Rijeka, Olge Ban 22, 51000 Rijeka, Yugoslavia
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Biserka Radosevic-Stasic;
Biserka Radosevic-Stasic
2Department of Physiology and Immunology Medical Faculty, University “Vladimir Bakaric” of Rijeka, Olge Ban 22, 51000 Rijeka, Yugoslavia
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Madena Kirigin;
Madena Kirigin
1Department of Chemistry and Biochemistry, University “Vladimir Bakaric” of Rijeka, Olge Ban 22, 51000 Rijeka, Yugoslavia
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Visnja Hinic;
Visnja Hinic
1Department of Chemistry and Biochemistry, University “Vladimir Bakaric” of Rijeka, Olge Ban 22, 51000 Rijeka, Yugoslavia
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Daniel Rukavina;
Daniel Rukavina
2Department of Physiology and Immunology Medical Faculty, University “Vladimir Bakaric” of Rijeka, Olge Ban 22, 51000 Rijeka, Yugoslavia
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Per-Olof Berggren;
Per-Olof Berggren
3Department of Endocrinology, Karolinska Institute, Stockholm, Sweden
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Saud Efendic
Saud Efendic
1Department of Chemistry and Biochemistry, University “Vladimir Bakaric” of Rijeka, Olge Ban 22, 51000 Rijeka, Yugoslavia
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Publisher: Portland Press Ltd
Received:
March 06 1990
Revision Requested:
August 07 1990
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1991 Plenum Publishing Corporation
1991
Biosci Rep (1991) 11 (1): 1–6.
Article history
Received:
March 06 1990
Revision Requested:
August 07 1990
Citation
Cedomila Milin, Biserka Radosevic-Stasic, Madena Kirigin, Visnja Hinic, Daniel Rukavina, Per-Olof Berggren, Saud Efendic; Somatostatin promotes accumulation of phospholipids in regenerating liver tissue of rats. Biosci Rep 1 February 1991; 11 (1): 1–6. doi: https://doi.org/10.1007/BF01118598
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