Coenzyme Q (CoQ0) and other quinones were shown to be potent insulin secretagogues in the isolated pancreatic islet. The order of potency was CoQ0≅benzoquinone≅hydroquinonemenadione. CoQ6 and CoQ10 (ubiquinone), duroquinone and durohydroquinone did not stimulate insulin release. CoQ0's insulinotropism was enhanced in calcium-free medium and CoQ0 appeared to stimulate only the second phase of insulin release. CoQ0 inhibited inositol mono-, bis- and trisphosphate formation. Inhibitors of mitochondrial respiration (rotenone, antimycin A, FCCP and cyanide) and the calcium channel blocker verapamil, did not inhibit CoQ0-induced insulin release. Dicumarol, an inhibitor of quinone reductase, did not inhibit CoQ0-induced insulin release, but it did inhibit glucose-induced insulin release suggesting that the enzyme and quinones play a role in glucose-induced insulin release. Quinones may stimulate insulin release by mimicking physiologically-occuring quinones, such as CoQ10, by acting on the plasma membrane or in the cytosol. Exogenous quinones may bypass the quinone reductase reaction, as well as many reactions important for exocytosis.
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June 01 1991
Stimulation of insulin release from pancreatic islets by quinones
Michael J. MacDonald
Michael J. MacDonald
1The Childrens Diabetes Center, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
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Publisher: Portland Press Ltd
Received:
May 17 1991
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1991 Plenum Publishing Corporation
1991
Biosci Rep (1991) 11 (3): 165–170.
Article history
Received:
May 17 1991
Citation
Michael J. MacDonald; Stimulation of insulin release from pancreatic islets by quinones. Biosci Rep 1 June 1991; 11 (3): 165–170. doi: https://doi.org/10.1007/BF01182485
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