Liver microsomes were enriched in liposomal acidic lipids by Ca2+-dependent fusion of liposomes at pH 7.0. The extent of fusion was monitored by the transfer of radioactive cholesteryl oleate. The enrichment of membranes in phosphatidylserine inhibited ethanolamine base-exchange, whereas the fusion with phosphatidylinositol inhibited both ethanolamine and serine base-exchange reactions. In contrast, these two phospholipids had scarce effects on choline base-exchange. Phosphatidic acid did not suppress any of the three base-exchange activities. Possible functional implications are discussed.
Research Article| October 01 1991
Regulation of liver base-exchange activity by acidic phospholipids
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Józef Zborowski, Lanfranco Corazzi, Giuseppe Arienti; Regulation of liver base-exchange activity by acidic phospholipids. Biosci Rep 1 October 1991; 11 (5): 231–236. doi: https://doi.org/10.1007/BF01127498
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