Water-soluble inositol metabolites were separated by anion-exchange chromatogrphy in order to determine whether or not γ-hexachlorocyclohexane (γ-HCH, lindane) and related compounds affect phosphatidylinositol hydrolysis in rat brain cortex slices. Hydrolysis was increased by δ-and γ-HCH, while α- and β-HCH were inactive. Muscarinic receptor stimulation of rat cortical slices with carbachol increases inositol phosphates formation. The combined effect of carbachol and the hexachlorocyclohexane isomers together were approximately equal to the sum of the effect of each one separately. The results suggest that lindane stimulates phosphoinositide phospholipase C and/or inhibits the phosphases implicated in dephosphorylation of inositol phosphates.
Skip Nav Destination
Article navigation
Rapid Communication|
April 01 1993
Characterization of phosphoinositide hydrolysis products induced by hexachlorocyclohexane isomers in rat brain cortex Available to Purchase
N. del Hoyo;
N. del Hoyo
1Departmento de Bioquímica y Biologia Molecular, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain
Search for other works by this author on:
J. A. Pulido;
J. A. Pulido
1Departmento de Bioquímica y Biologia Molecular, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain
Search for other works by this author on:
M. A. Pérez-Albarsanz
M. A. Pérez-Albarsanz
1Departmento de Bioquímica y Biologia Molecular, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
January 28 1993
Accepted:
March 03 1993
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1993 Plenum Publishing Corporation
1993
Biosci Rep (1993) 13 (2): 119–126.
Article history
Received:
January 28 1993
Accepted:
March 03 1993
Citation
N. del Hoyo, J. A. Pulido, M. A. Pérez-Albarsanz; Characterization of phosphoinositide hydrolysis products induced by hexachlorocyclohexane isomers in rat brain cortex. Biosci Rep 1 April 1993; 13 (2): 119–126. doi: https://doi.org/10.1007/BF01145964
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |