The unicellular tetrahymena contains inositol phospholipids (PI, PIP, PIP2) and GPIs. Treatment with 10−5M insulin decreases the total 3H-inositol incorporation and incorporation into PI. 24 h after 10−6M insulin treatment there is an elevation of these parameters. Second treatment with 10−6M insulin doubles and 10−5M decreases these levels. This means that the effect on phosphoinositide turnover by insulin in Tetrahymena is rather concentration dependent. Inositol incorporation into GPIs is also influenced by insulin.

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