Ca2+-uptake into intracellular stores is mediated by the sarco/endoplasmic reticulum Ca2+ATPases (SERCAs). This review deals first with the gene structural and the characterization of the tissue-specific SERCA2 transcript processing. Secondly, the two different protein isoforms and their regulation are described. Finally, this review ends with a discussion on the possible physiological role of the SERCA2 isoform diversity.
Modulation of SERCA2 activity: Regulated splicing and interaction with phospholamban
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Hilde Verboomen, Luc Mertens, Jan Eggermont, Frank Wuytack, Ludo Van Den Bosch; Modulation of SERCA2 activity: Regulated splicing and interaction with phospholamban. Biosci Rep 1 October 1995; 15 (5): 307–315. doi: https://doi.org/10.1007/BF01788363
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