Cystic fibrosis (CF) affects approximately 1 in 2000 people making it one of the commonest fatal, inherited diseases in the Caucasian population. CF is caused by mutations in a cyclic AMP-regulated chloride channel known as CFTR, which is found on the apical plasma membrane of many exocrine epithelial cells. In the CF pancreas, dysfunction of the CFTR reduces the secretory activity of the tubular duct cells, which leads to blockage of the ductal system and eventual fibrosis of the whole gland. One possible approach to treating the disease would be to activate an alternative chloride channel capable of bypassing defective CFTR. A strong candidate for this is a chloride channel regulated by intracellular calcium, which has recently been shown to protect the pancreas in transgenic CF mice. Pharmacological intervention directed at activating this calcium-activated Cl− conductance might provide a possible therapy to treat the problems of pancreatic dysfunction in CF.
Skip Nav Destination
Article navigation
Research Article|
December 01 1995
Chloride channels and cystic fibrosis of the pancreas
M. A. Gray;
M. A. Gray
1Department of Physiological Sciences, University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
Search for other works by this author on:
J. P. Winpenny;
J. P. Winpenny
1Department of Physiological Sciences, University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
Search for other works by this author on:
B. Verdon;
B. Verdon
1Department of Physiological Sciences, University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
Search for other works by this author on:
H. McAlroy;
H. McAlroy
1Department of Physiological Sciences, University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
Search for other works by this author on:
B. E. Argent
B. E. Argent
1Department of Physiological Sciences, University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 08 1995
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1995 Plenum Publishing Corporation
1995
Biosci Rep (1995) 15 (6): 531–541.
Article history
Received:
September 08 1995
Citation
M. A. Gray, J. P. Winpenny, B. Verdon, H. McAlroy, B. E. Argent; Chloride channels and cystic fibrosis of the pancreas. Biosci Rep 1 December 1995; 15 (6): 531–541. doi: https://doi.org/10.1007/BF01204355
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |