Cell-swelling, induced by a hyposmotic shock, activates the release of taurine from lactating rat mammary tissue expiants. The degree of stimulation of taurine efflux was dependent upon the extent of cell-swelling. Volume-sensitive taurine release was attenuated by the anion transport inhibitors NPPB, DIOA, DIDS, niflumate, flufenamate, mefenamate and diiodosalicylate but not by salicylate. Cell-swelling, following a hyposmotic challenge, did not increase the unidirectional efflux of radiolabelled I− or D-asparate from mammary tissue expiants. The results suggest that although mammary tissue expresses a volume-sensitive amino acid transport system which is inhibited by anion transport blockers the pathway has no identity with volume-activated anion channels.
Volume-sensitive taurine efflux from mammary tissue is not obliged to utilize volume-activated anion channels
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D. B. Shennan, M. J. Cliff, P. Hawkins; Volume-sensitive taurine efflux from mammary tissue is not obliged to utilize volume-activated anion channels. Biosci Rep 1 December 1996; 16 (6): 459–465. doi: https://doi.org/10.1007/BF01198461
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