The experiments leading to the discovery of MHC-restricted T-cell killing of virus-infected cells are described. The implications of MHC- and HLA-restricted T-cell killing for the development of new vaccines and for the understanding of autoimmune disease are discussed.
Keywords:
Cell mediated immunity,
histocompatibility complex,
immunity,
MHC,
T cell,
virus infection
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© 1997 Plenum Publishing Corporation
1997
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