New facts and ideas concerning the membrane-linked mechanisms preventing superoxide formation are summarised here. It is assumed that aerobic cells possess several lines of anti-ROS defence, including optimisation of the intracellular oxygen concentration, decrease in the concentration and life-time of one-electron O2 reductants such as CoQH; and mitochondrial and cell selections, i.e. elimination of mitochondria and cells producing ROS at high rate. It is postulated that ROS-dependent pore opening and ROS-dependent apoptosis are involved in mitochondrial and cell selections.
Review Article| June 01 1997
Membrane-Linked Systems Preventing Superoxide Formation
Biosci Rep (1997) 17 (3): 347–366.
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Vladimir P. Skulachev; Membrane-Linked Systems Preventing Superoxide Formation. Biosci Rep 1 June 1997; 17 (3): 347–366. doi: https://doi.org/10.1023/A:1027344914565
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