The perforated patch clamp method was used to study the effect of the agonist of beta-adrenoreceptors isoproterenol on L-type Ca2+ current in cardiocytes of rats and ground squirrels in two states: active and hibernating. It is shown that isoproterenol exerts a dual effect on Ca2+ currents of rats and ground squirrels in the active state: at Vh = −50 mV, the current increases, whereas at Vh = −30 mV, it decreases. In hibernating ground squirrels, the dual effect of isoproterenol is not observed: isoproterenol increases Ca2+ current at any Vh values. The hypothesis is put forward that, during the entrance of ground squirrels into hibernation, the phosphorylation of one of the sites (not cAMP-dependent) of L-type Ca2+ channels is blocked.
Effect of Isoproterenol on the L-type Ca2+ Current in Cardiac Cells from Rats and Hybernating Ground Squirrels
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Yu. M. Kokoz, A. S. Grichenko, A. F. Korystova, D. A. Lankina, N. I. Markevich; Effect of Isoproterenol on the L-type Ca2+ Current in Cardiac Cells from Rats and Hybernating Ground Squirrels. Biosci Rep 1 February 1999; 19 (1): 17–25. doi: https://doi.org/10.1023/A:1020141922904
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