Leukocyte adhesion is of pivotal functional importance, because most leukocyte functions depend on cell–cell contact. It must be strictly controlled, both at the level of specificity and strength of interaction, and therefore several molecular systems are involved. The most important leukocyte adhesion molecules are the selectins, the leukocyte-specific β2-integrins and the intercellular adhesion molecules. The selectins induce an initial weak contact between cells, whereas firm adhesion is achieved through integrin–intercellular adhesion molecular binding. Although studies during the past twenty years have revealed several important features of leukocyte adhesion much is still poorly understood, and further work dealing with several aspects of adhesion is urgently needed. In this short essay, we review some recent developments in the field.
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Research Article|
August 01 1999
Leukocyte Adhesion’an Integrated Molecular Process at the Leukocyte Plasma Membrane
Carl G. Gahmberg;
Carl G. Gahmberg
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Leena Valmu;
Leena Valmu
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Annika Kotovuori;
Annika Kotovuori
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Pekka Kotovuori;
Pekka Kotovuori
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Tiina J. Hilden;
Tiina J. Hilden
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Susanna Fagerholm;
Susanna Fagerholm
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Carmela Kantor;
Carmela Kantor
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Tuula Nurminen;
Tuula Nurminen
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Eveliina Ihanus;
Eveliina Ihanus
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Li Tian
Li Tian
1Department of Biosciences, Division of Biochemistry, University of Helsinki, P.O. Box 56, (Viikinkaari 5), FIN-00014, Finland;
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Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1999 Plenum Publishing Corporation
1999
Biosci Rep (1999) 19 (4): 273–281.
Citation
Carl G. Gahmberg, Leena Valmu, Annika Kotovuori, Pekka Kotovuori, Tiina J. Hilden, Susanna Fagerholm, Carmela Kantor, Tuula Nurminen, Eveliina Ihanus, Li Tian; Leukocyte Adhesion’an Integrated Molecular Process at the Leukocyte Plasma Membrane. Biosci Rep 1 August 1999; 19 (4): 273–281. doi: https://doi.org/10.1023/A:1020594223755
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