The chimæric channel, 4N/1, generated from two outwardly rectifying K+ channels by linking the N-terminal cytoplasmic domain of hKv1.4 with the transmembrane body of hKv1.1, functions as an inward rectifier. The operating range of the channel is shifted to hyperpolarizing potentials and it is inactivated at resting membrane potentials. Co-expression of a truncated form of hKv1.1 with the N-terminal domain of hKv1.4 results in the same physiology as the chimæra implying specific interactions between the two segments.
Exploring the Architecture of Potassium Channels Using Chimæras to Reveal Signal Transduction
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Baron Chanda, J. K. Tiwari, Anurag Varshney, M. K. Mathew; Exploring the Architecture of Potassium Channels Using Chimæras to Reveal Signal Transduction. Biosci Rep 1 August 1999; 19 (4): 301–306. doi: https://doi.org/10.1023/A:1020550408733
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