We have identified and isolated two forms of insulin receptor from rat-liver plasma membranes. The smaller (Mr = 90k) is a single polypeptide. The same poly-peptide appears to be the insulin-binding site of the largerMr = 280k). Only the larger, multisubunit, receptor shows high-affinity binding of insulin and negative cooperativity in its dissociation kinetics.
Research Article| October 01 1982
Characterization of two insulin-binding components of rat-liver plasma membranes
M. D. Baron;
- Views Icon Views
- Share Icon Share
M. D. Baron, P. H. Sónksen; Characterization of two insulin-binding components of rat-liver plasma membranes. Biosci Rep 1 October 1982; 2 (10): 785–793. doi: https://doi.org/10.1007/BF01114938
Download citation file: