Under conditions favoring lipogenesis, a high-molecular-weight species of acetyl-CoA carboxylase was isolated that did not co-sediment with the in vitro polymerized enzyme. Assays for ATP-citrate lyase, acetyl-CoA carboxylase, and fatty acid synthetase indicated that all three enzymes were associated together as a high-molecular-weight complex and that under low-lipogenic conditions the level of these enzymes decreased. Phosphorylation of the isolated complex shifted it toward a lower molecular weight.
Research Article| October 01 1982
Rat-liver fatty-acid-synthesizing complex
P. M. Gillevet;
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P. M. Gillevet, K. Dakshinamurti; Rat-liver fatty-acid-synthesizing complex. Biosci Rep 1 October 1982; 2 (10): 841–848. doi: https://doi.org/10.1007/BF01114945
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