Phytohaemagglutinin-stimulated and non-stimulated incorporation of [3H]thymidine into human peripheral blood lymphocytes is inhibited by the calcium antagonist PY 108–068 and by the calmodulin antagonists trifluo-perazine and N-(6-aminohexyl)-5-chloro-l-naphthalene sulphonamide (W7). It is argued that calmodulin may be involved in both non-stimulated [3H]thymidine uptake in lymphocytes and also in the lymphocyte response to phytohaemagglutinin.
Evidence that calmodulin may be involved in phytohaemagglutinin-stimulated lymphocyte division
- Views Icon Views
- Share Icon Share
Sheila Mac Neil, S. W. Walker, B. L. Brown, S. Tomlinson; Evidence that calmodulin may be involved in phytohaemagglutinin-stimulated lymphocyte division. Biosci Rep 1 November 1982; 2 (11): 891–897. doi: https://doi.org/10.1007/BF01114895
Download citation file: