Phytohaemagglutinin-stimulated and non-stimulated incorporation of [3H]thymidine into human peripheral blood lymphocytes is inhibited by the calcium antagonist PY 108–068 and by the calmodulin antagonists trifluo-perazine and N-(6-aminohexyl)-5-chloro-l-naphthalene sulphonamide (W7). It is argued that calmodulin may be involved in both non-stimulated [3H]thymidine uptake in lymphocytes and also in the lymphocyte response to phytohaemagglutinin.

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