Macrophages from C57BL/6J mice, an animal susceptible toatherosclerosis, were chosen as target cells to study changes in thetransmembrane Ca2+adient during the formation ofmacrophage-derived foam cells. The transmembrane Ca2+adientsof single living cells were examined using Fura-2/AM combined withFluo-3/AM by laser scanning confocal microscopy. Exposure to OxidizedLow Density Lipoprotein, decreases the Ca2+adient acrossmacrophage plasma membrane, but increases that across the nuclearmembrane. The altered transmembrane Ca2+adients could inducethe up-regulation of scavenger receptor in macrophages, resulting inthe formation of foam cells.

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