In this chapter we shall describe how to apply the hydrophobicity-at-interface scale, as proposed by Wimley and White [Wimley, W. C. and White, S. H. (1996) Nature Struct. Biol. 3:842–848], to the detection of amino acid sequences of viral envelope glycoproteins putatively engaged in interactions with the target membranes. In addition, a new approach will be briefly introduced to infer the bilayer location at equilibrium of membrane-partitioning sequences. The use of these new procedures may be important in describing the molecular mechanism leading to the formation of a fusion pore by viral glycoproteins.
Research Article| December 01 2000
Hydrophobic-at-Interface Regions in Viral Fusion Protein Ectodomains
José L. Nieva;
Biosci Rep (2000) 20 (6): 519–533.
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José L. Nieva, Tatiana Suárez; Hydrophobic-at-Interface Regions in Viral Fusion Protein Ectodomains. Biosci Rep 1 December 2000; 20 (6): 519–533. doi: https://doi.org/10.1023/A:1010458904487
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