Type 2 diabetes (or non-insulin dependent diabetes mellitus, NIDDM) is a common metabolic disease in man. The Goto–Kakizaki (GK) rat has been designed as a NIDDM model. Previous studies with this strain have shown differences at the mitochondrial level. The mitochondrial permeability transition (MPT) is a widely studied phenomenon but yet poorly understood, that leads to mitochondrial dysfunction and cell death. The aim of this work was to compare the differences in susceptibility of induction of the MPT with calcium phosphate in GK and Wistar rats. Our results show that heart mitochondria from GK rats are less susceptible to the induction of MPT, and show a larger calcium accumulation before the overall loss of mitochondrial impermeability.
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February 01 2001
Decreased Susceptibility of Heart Mitochondria from Diabetic GK Rats to Mitochondrial Permeability Transition Induced by Calcium Phosphate
Paulo J. Oliveira;
Paulo J. Oliveira
1Centro de Neurociências de Coimbra, Dep. Zoologia, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal
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Anabela P. Rolo;
Anabela P. Rolo
1Centro de Neurociências de Coimbra, Dep. Zoologia, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal
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R. Seiça;
R. Seiça
2Faculdade de Medicina, Centro de Neurociências de Coimbra de Coimbra, Universidade de Coimbra, Portugal
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Carlos M. Palmeira;
Carlos M. Palmeira
1Centro de Neurociências de Coimbra, Dep. Zoologia, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal
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M. S. Santos;
M. S. Santos
1Centro de Neurociências de Coimbra, Dep. Zoologia, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal
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António J. M. Moreno
António J. M. Moreno
1Centro de Neurociências de Coimbra, Dep. Zoologia, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Portugal
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Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 2001 Plenum Publishing Corporation
2001
Biosci Rep (2001) 21 (1): 45–53.
Citation
Paulo J. Oliveira, Anabela P. Rolo, R. Seiça, Carlos M. Palmeira, M. S. Santos, António J. M. Moreno; Decreased Susceptibility of Heart Mitochondria from Diabetic GK Rats to Mitochondrial Permeability Transition Induced by Calcium Phosphate. Biosci Rep 1 February 2001; 21 (1): 45–53. doi: https://doi.org/10.1023/A:1010482017540
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