Synthetic onlays that are implanted onto the surface of the cornea have the potential to become an alternative to spectacles and contact lenses for the correction of refractive error. A successful corneal onlay is dependent on development of a biocompatible polymer material that will maintain a healthy cornea after implantation and that will promote growth of corneal epithelial cells over the onlay, and development of a method for attachment of the onlay with minimal surgical invasiveness. The ideal onlay should be made of a material that is highly permeable yet has sufficient surface characteristics to stimulate stable and firm attachment of the corneal epithelium over the onlay. Recent research indicates that collagen I coated polymer materials that mimic the basement membrane of the corneal epithelium promote the most favorable growth of epithelial cells in vivo in comparison to wholly biological or synthetic materials.
Skip Nav Destination
Article navigation
Research Article|
August 01 2001
Artificial Cornea: Towards a Synthetic Onlay for Correction of Refractive Error
Ruo Zhong Xie;
Ruo Zhong Xie
1The Cooperative Research Centre for Eye Research and Technology (CRCERT), The University of New South Wales, Sydney, Australia
Search for other works by this author on:
Serina Stretton;
Serina Stretton
1The Cooperative Research Centre for Eye Research and Technology (CRCERT), The University of New South Wales, Sydney, Australia
Search for other works by this author on:
Deborah F. Sweeney
Deborah F. Sweeney
1The Cooperative Research Centre for Eye Research and Technology (CRCERT), The University of New South Wales, Sydney, Australia
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 2001 Plenum Publishing Corporation
2001
Biosci Rep (2001) 21 (4): 513–536.
Citation
Ruo Zhong Xie, Serina Stretton, Deborah F. Sweeney; Artificial Cornea: Towards a Synthetic Onlay for Correction of Refractive Error. Biosci Rep 1 August 2001; 21 (4): 513–536. doi: https://doi.org/10.1023/A:1017900111663
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |