Previous studies demonstrated that the adaptive response to stressors and inflammatory signals involves the activation of the automotic nervous system. Catecholamines have been shown to modulate the activity of various immune effector cells directly via membrane adrenergic receptors. Here, we investigated immediate effects of norepinephrine on energy metabolism of immune cells. Norepinephrine inhibits oxygen consumption of human peripheral blood mononuclear cells at concentrations that are relevant to its physiological range. The ?-adrenoreceptor antagonist propranolol, but not the ?-adrenoreceptor antagonist phentolamine reversed the norepinephrine induced inhibition in quiescent cells. Conversely, phentolamine but not propranolol is capable of blocking norepinephrine mediated effects in mitogen activated human peripheral blood mononuclear cells. Our data indicate that the sensitization of ?- and ?-adrenoreceptors on immune cells is differentially regulated, and that these processes depend on the activation state of these cells. These findings have important implications for the understanding of stress-induced suppression of immune function and may contribute to the elucidation of the pathogenesis of immunologically mediated diseases.
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Research Article|
October 01 2001
Norepinephrine Inhibits Energy Metabolism of Human Peripheral Blood Mononuclear Cells via Adrenergic Receptors
Jan D. Lünemann;
Jan D. Lünemann
1Department of Neurology, Division of Neuroimmunology, Charité, University Hospital, Berlin, Germany
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Frank Buttgereit;
Frank Buttgereit
2Department of Medicine, Rheumatology and Clinical Immunology, Charité, University Hospital, Berlin, Germany
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Robert Tripmacher;
Robert Tripmacher
2Department of Medicine, Rheumatology and Clinical Immunology, Charité, University Hospital, Berlin, Germany
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Christoph G. O. Baerwald;
Christoph G. O. Baerwald
3Department of Rheumatology, University Hospital, Leipzig, Germany
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Gerd-Rüdiger Burmester;
Gerd-Rüdiger Burmester
2Department of Medicine, Rheumatology and Clinical Immunology, Charité, University Hospital, Berlin, Germany
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Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 2001 Plenum Publishing Corporation
2001
Biosci Rep (2001) 21 (5): 627–635.
Connected Content
A correction has been published:
Erratum: Jan Lünemann, Frank Buttgereit, Robert Tripmacher, Christoph G. O. Baerwald, Gerd-Rüdiger Burmester, and Andreas Krause, “Norepinephrine Inhibits Energy Metabolism of Human Peripheral Blood Mononuclear Cells via Adrenergic Receptors,” Bioscience Reports, Vol. 21, No. 5, p. 627
Citation
Jan D. Lünemann, Frank Buttgereit, Robert Tripmacher, Christoph G. O. Baerwald, Gerd-Rüdiger Burmester, Andreas Krause; Norepinephrine Inhibits Energy Metabolism of Human Peripheral Blood Mononuclear Cells via Adrenergic Receptors. Biosci Rep 1 October 2001; 21 (5): 627–635. doi: https://doi.org/10.1023/A:1014768909442
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