Ingestion of the mycotoxin Aflatoxin B1 (AFB1) by protein-undernourished Fischer F344 rats for twelve weeks resulted in significant (p<0.05) increases in the proliferation of liver cells, reduced body weight and increased microsomal Ca2+-ATPase activity. Cyt. P450 content, γ -Glutamyl Transferase (GGT) and Glutathione Transferase (GST) activities were unaffected. The ingestion of AFB1 by normal rats had no effect on all the parameters investigated. It appears that the microsomal Ca2+-pumping ATPase of Protein-Undernourished (PU) Fischer F344 rats is more sensitive to the mycotoxin AFB1 than its counterpart in well-nourished rats. The use of PU rat as animal model for studies on AFB1 toxicity, particularly the effect of AFB1 on the regulation of intracellular calcium ion concentration ([Ca2+]i), is suggested.
Skip Nav Destination
Article navigation
Research Article|
December 01 2001
Consequence of Aflatoxin B1 Ingestion on the Membrane-Bound Liver Endoplasmic Reticulum Ca2+-ATPase of Protein-Undernourished Fischer F344 Rats
Gbenga A. Adenuga
Gbenga A. Adenuga
1Department of Biochemistry, Olabisi Onabanjo University, P.M.B. 2002, Ago-Iwoye, Ogun State, Nigeria
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 2001 Plenum Publishing Corporation
2001
Biosci Rep (2001) 21 (6): 873–877.
Citation
Gbenga A. Adenuga; Consequence of Aflatoxin B1 Ingestion on the Membrane-Bound Liver Endoplasmic Reticulum Ca2+-ATPase of Protein-Undernourished Fischer F344 Rats. Biosci Rep 1 December 2001; 21 (6): 873–877. doi: https://doi.org/10.1023/A:1015597026959
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |