Several improvements have been made in liposomal delivery, thus making this technology potentially useful for treatment of certain diseases in the clinic. Success in non-viral delivery is complicated and requires optimization of several components. These components include nucleic acid purification, plasmid design, formulation of the delivery vehicle, administration route and schedule, dosing, detection of gene expression, and others. With further improvements, broad use of non-viral delivery systems to treat human disorders should be possible.
Research Article| April 01 2002
Cationic Liposome-Mediated Gene Delivery In vivo
Biosci Rep (2002) 22 (2): 283–295.
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Nancy Smyth Templeton; Cationic Liposome-Mediated Gene Delivery In vivo. Biosci Rep 1 April 2002; 22 (2): 283–295. doi: https://doi.org/10.1023/A:1020142823595
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