Uncoupling mitochondrial proteins (UCPs) belong to a discrete family within the mitochondrial anion carrier superfamily. Several uncoupling protein types have been found in mitochondria from mammals and plants, as well as in fishes, fungi, and protozoa. Mammalian UCPs and plant uncoupling proteins (PUMPs) form five distinct subfamilies. Only subfamily III contains both plant and animal uncoupling proteins, as well as UCPs from primitive eukaryotic organisms, which suggest that this group may represent an ancestral cluster from which other UCPs/PUMPs may have evolved. Genetic data indicate that UCPs/PUMPs are regulated at the transcriptional, post-transcriptional, and translational levels. Tissue/organ- and stress-specific gene expression suggests that UCPs/PUMPs are involved in the general balance of basic energy expenditure, protection against reactive oxygen species, and thermogenesis. Finally, the simultaneous occurrence of PUMP and alternative oxidase, another energy-dissipating system in plant mitochondria, raises the question of their response to biotic and abiotic stress at the transcriptional and functional levels.
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Review Article|
June 08 2005
Genomic Structure and Regulation of Mitochondrial Uncoupling Protein Genes in Mammals and Plants
Fábio T. S. Nogueira;
Fábio T. S. Nogueira
1Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas (UNICAMP), 13083-970, Campinas, SP, Brazil
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Jiri Borecký;
Jiri Borecký
1Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas (UNICAMP), 13083-970, Campinas, SP, Brazil
2Departamento de Patologia Clínica (NMCE), Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), 13083-970, Campinas, SP, Brazil
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Aníbal E. Vercesi;
Aníbal E. Vercesi
2Departamento de Patologia Clínica (NMCE), Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), 13083-970, Campinas, SP, Brazil
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Paulo Arruda
Paulo Arruda
1Centro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas (UNICAMP), 13083-970, Campinas, SP, Brazil
3Departamento de Genética e Evolução, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), 13083-970, Campinas, SP, Brazil
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Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 2005 Springer Science+Business Media, Inc.
2005
Biosci Rep (2005) 25 (3-4): 209–226.
Citation
Fábio T. S. Nogueira, Jiri Borecký, Aníbal E. Vercesi, Paulo Arruda; Genomic Structure and Regulation of Mitochondrial Uncoupling Protein Genes in Mammals and Plants. Biosci Rep 8 June 2005; 25 (3-4): 209–226. doi: https://doi.org/10.1007/s10540-005-2886-5
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