Multiple blood cell types and metabolic pathways involved in the modulation of platelet reactivity were investigated in streptozotocin-induced diabetic rats treated with garlic oil. Platelet counts of diabetic rats treated with garlic oil were significantly (P<0.01) reduced as compared to diabetic control rats. Garlic oil also increased the leucocyte counts of diabetic rats as compared to diabetic control rats. The significant (P<0.001) decreases by garlic oil of plasma concentration factors, V, VII, VIII: C, IX and X in diabetic rats may be interpreted to mean that there was a modulation of factor VII similar to that brought about by thrombin on factors V and VIII: C. This reversal of hypercoagulation through integrated biochemical reaction is suggestive of multicellular modulation of platelet reactivity, erythrocytes and neutrophils and the functional interactions between plasma coagulation factors and platelet cofactors.
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June 15 2006
Anticoagulant Modulation of Blood Cells and Platelet Reactivity by Garlic Oil in Experimental Diabetes Mellitus
O.C. Ohaeri;
O.C. Ohaeri
1Department of Biochemistry, Faculty of Medical Sciences, University of JOS, JOS, Nigeria
2Department of Chemical Sciences, Michael Okpara University of Agriculture, Umudike, PMB 7267, Umuahia, Abia state, Nigeria
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G. I. Adoga
G. I. Adoga
1Department of Biochemistry, Faculty of Medical Sciences, University of JOS, JOS, Nigeria
2Department of Chemical Sciences, Michael Okpara University of Agriculture, Umudike, PMB 7267, Umuahia, Abia state, Nigeria
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Publisher: Portland Press Ltd
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 2006 Springer Science+Business Media, Inc.
2006
Biosci Rep (2006) 26 (1): 1–6.
Citation
O.C. Ohaeri, G. I. Adoga; Anticoagulant Modulation of Blood Cells and Platelet Reactivity by Garlic Oil in Experimental Diabetes Mellitus. Biosci Rep 15 June 2006; 26 (1): 1–6. doi: https://doi.org/10.1007/s10540-006-9004-1
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