In the course of evolution, mitochondria lost their independence, and mtDNA became “slave” of nDNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause diseases that affect mtDNA integrity or expression, being inherited as mendelian traits.
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Research Article| June 13 2007
Disorders of Nuclear-Mitochondrial Intergenomic Communication
Biosci Rep (2007) 27 (1-3): 39–51.
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Antonella Spinazzola, Massimo Zeviani; Disorders of Nuclear-Mitochondrial Intergenomic Communication. Biosci Rep 13 June 2007; 27 (1-3): 39–51. doi: https://doi.org/10.1007/s10540-007-9036-1
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