Heterogeneity of genome content is commonly observed in axenic cultures of Entamoeba histolytica. Cells with multiple nuclei and nuclei with heterogenous genome contents suggest that regulatory mechanisms that ensure alternation of DNA synthesis and mitosis are absent in this organism. Therefore, several endo-reduplicative cycles may occur without mitosis. The data also shows that unlike other endo-reduplicating organisms, E. histolytica does not undergo a precise number of endo-reduplicative cycles. We propose that irregular endo-reduplication and genome partitioning lead to heterogeneity in the genome content of E. histolytica trophozoites in their proliferative phase. The goal of future studies should be aimed at understanding the mechanisms that are involved in (a) accumulation of multiple genome contents in a single nucleus; (b) genome segregation in nuclei that contain multiple genome contents and (c) maintenance of genome fidelity in E. histolytica.
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Research Article|
November 20 2007
Genome Re-duplication and Irregular Segregation Occur During the Cell Cycle of Entamoeba histolytica
Anuradha Lohia;
Anuradha Lohia
1Department of Biochemistry, Bose Institute, Kolkata 700054, India
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Chandrama Mukherjee;
Chandrama Mukherjee
1Department of Biochemistry, Bose Institute, Kolkata 700054, India
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Shubhra Majumder;
Shubhra Majumder
1Department of Biochemistry, Bose Institute, Kolkata 700054, India
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Promita Ghosh Dastidar
Promita Ghosh Dastidar
1Department of Biochemistry, Bose Institute, Kolkata 700054, India
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Biosci Rep (2007) 27 (6): 373–384.
Citation
Anuradha Lohia, Chandrama Mukherjee, Shubhra Majumder, Promita Ghosh Dastidar; Genome Re-duplication and Irregular Segregation Occur During the Cell Cycle of Entamoeba histolytica. Biosci Rep 20 November 2007; 27 (6): 373–384. doi: https://doi.org/10.1007/s10540-007-9058-8
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