The influence of caloric restriction on hepatic glyceraldehyde- and glycerol-metabolizing enzyme activities of young and old mice were studied. Glycerol kinase and cytoplasmic glycerol-3-phosphate dehydrogenase activities were increased in both young and old CR (calorie-restricted) mice when compared with controls, whereas triokinase increased only in old CR mice. Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction. Mitochondrial glycerol-3-phosphate dehydrogenase showed a trend towards an increased activity in old CR mice, whereas a trend towards a decreased activity in alcohol dehydrogenase was observed in both young and old CR mice. Serum glycerol levels decreased in young and old CR mice. Therefore increases in glycerol kinase and glycerol-3-phosphate dehydrogenase were associated with a decrease in fasting blood glycerol levels in CR animals. A prominent role for triokinase in glyceraldehyde metabolism with CR was also observed. The results indicate that long-term caloric restriction induces sustained increases in the capacity for gluconeogenesis from glycerol.
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Research Article|
May 16 2008
Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities
Kevork Hagopian;
Kevork Hagopian
1
* Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.
1 To whom correspondence should be addressed ([email protected]).
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Jon J. Ramsey;
Jon J. Ramsey
* Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, U.S.A.
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Richard Weindruch
Richard Weindruch
† Department of Medicine, University of Wisconsin Medical School, Madison, WI 53706, U.S.A.
‡ Geriatric Research, Educational and Clinical Center, William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, U.S.A.
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Publisher: Portland Press Ltd
Received:
February 22 2008
Revision Received:
April 09 2008
Accepted:
April 23 2008
Accepted Manuscript online:
April 23 2008
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biosci Rep (2008) 28 (2): 107–115.
Article history
Received:
February 22 2008
Revision Received:
April 09 2008
Accepted:
April 23 2008
Accepted Manuscript online:
April 23 2008
Citation
Kevork Hagopian, Jon J. Ramsey, Richard Weindruch; Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities. Biosci Rep 1 April 2008; 28 (2): 107–115. doi: https://doi.org/10.1042/BSR20080015
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