Constant generation of ROS (reactive oxygen species) during normal cellular metabolism of an organism is generally balanced by a similar rate of consumption by antioxidants. Imbalance between ROS production and antioxidant defence results in an increased level of ROS, causing oxidative stress, which leads to promotion of malignancy. Queuine is a hyper-modified base analogue of guanine, found at the first anticodon position of the Q-family of tRNAs. These tRNAs are completely modified with respect to queuosine in terminally differentiated somatic cells; however, hypo-modification of Q-tRNAs is closely associated with cell proliferation. Q-tRNA modification is essential for normal development, differentiation and cellular function. Queuine is a nutrient factor for eukaryotes. It is found to promote the cellular antioxidant defence system and inhibit tumorigenesis. The activities of antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase are found to be low in the DLAT (Dalton's lymphoma ascites transplanted) mouse liver compared with normal mouse liver. However, exogenous administration of queuine to the DLAT cancerous mouse improves the activities of antioxidant enzymes. These results suggest that queuine promotes the antioxidant defence system by increasing antioxidant enzyme activities and in turn inhibits oxidative stress and tumorigenesis.
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Research Article|
April 11 2008
Queuine promotes antioxidant defence system by activating cellular antioxidant enzyme activities in cancer
Chandramani Pathak;
Chandramani Pathak
* Biochemistry and Molecular Biology Laboratory, Center of Advanced Study in Zoology, Banaras Hindu University, Varanasi-221005, India
† School of Studies in Biochemistry, Jiwaji University, Gwalior-474011, India
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Yogesh K. Jaiswal;
Yogesh K. Jaiswal
† School of Studies in Biochemistry, Jiwaji University, Gwalior-474011, India
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Manjula Vinayak
Manjula Vinayak
1
* Biochemistry and Molecular Biology Laboratory, Center of Advanced Study in Zoology, Banaras Hindu University, Varanasi-221005, India
1 To whom correspondence should be addressed (email [email protected].).
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Publisher: Portland Press Ltd
Received:
November 26 2007
Revision Received:
February 06 2008
Accepted:
February 22 2008
Accepted Manuscript online:
February 22 2008
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biosci Rep (2008) 28 (2): 73–81.
Article history
Received:
November 26 2007
Revision Received:
February 06 2008
Accepted:
February 22 2008
Accepted Manuscript online:
February 22 2008
Citation
Chandramani Pathak, Yogesh K. Jaiswal, Manjula Vinayak; Queuine promotes antioxidant defence system by activating cellular antioxidant enzyme activities in cancer. Biosci Rep 1 April 2008; 28 (2): 73–81. doi: https://doi.org/10.1042/BSR20070011
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