In the present paper, we examined the incidence of polymorphic genes involved with the detoxification of exogenous chemicals, including carcinogens, namely GSTT1 (glutathione transferase θ1), GSTM1 (glutathione transferase μ1) and NQO1 (NAD(P)H:quinone oxidoreductase 1) in 60 Filipino children with ALL (acute lymphoblastic leukaemia). We found a significantly high incidence of the GSTM1 null genotype in ALL children (71.7%) compared with 51.7% in the control group of children (P<0.05). The GSTT1 null genotype was observed in 35.0% and 33.3% of the ALL cases and the control subjects respectively, with no significant difference. Screening for NQO1 (609C>T) mutant alleles showed a high incidence of the NQO1 C/C genotype (NQO1 homozygous wild-type allele genotype) in 60.0% of ALL cases and was significantly higher than in the control group (23.3%) (P<0.01). These GSTM1 null and NQO1 wild-type genotypes are independently associated with the risk of ALL in Filipino patients. When these two genotypes, GSTM1 null and NQO1 C/C, were combined, the hazard rate for childhood leukaemia was significantly increased (P<0.001). We also noticed that the incidences of GSTM1 null mutations and the NQO1 C/C genotype were significantly higher among Filipinos. These findings suggest a possible role of the GSTM1 null and NQO1 C/C genotypes in the susceptibility of paediatric ALL cases in the Philippines.
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Research Article|
June 23 2008
Prevalence of GSTT1, GSTM1 and NQO1 (609C>T) in Filipino children with ALL (acute lymphoblastic leukaemia)1
Marilyn G. Rimando;
Marilyn G. Rimando
*Department of Biological Sciences, College of Science, University of Santo Tomas, Manila, The Philippines
†Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
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Mary N. Chua;
Mary N. Chua
‡Department of Pediatric Oncology–Hematology, University of Santo Tomas Hospital, Manila, Philippines
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Ernesto d'J. Yuson;
Ernesto d'J. Yuson
§Hematology Unit, The Children's Medical Center, Quezon City 1100, The Philippines
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Gloria de Castro-Bernas;
Gloria de Castro-Bernas
∥Research Center for the Natural Sciences, University of Santo Tomas, Manila, The Philippines
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Takashi Okamoto
Takashi Okamoto
2
*Department of Biological Sciences, College of Science, University of Santo Tomas, Manila, The Philippines
†Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
2To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
October 30 2007
Revision Received:
April 17 2008
Accepted:
April 30 2008
Accepted Manuscript online:
April 30 2008
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biosci Rep (2008) 28 (3): 117–124.
Article history
Received:
October 30 2007
Revision Received:
April 17 2008
Accepted:
April 30 2008
Accepted Manuscript online:
April 30 2008
Citation
Marilyn G. Rimando, Mary N. Chua, Ernesto d'J. Yuson, Gloria de Castro-Bernas, Takashi Okamoto; Prevalence of GSTT1, GSTM1 and NQO1 (609C>T) in Filipino children with ALL (acute lymphoblastic leukaemia). Biosci Rep 1 June 2008; 28 (3): 117–124. doi: https://doi.org/10.1042/BSR20070010
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