The development of MDR (multidrug resistance) in yeast is due to a number of mechanisms. The most documented mechanism is enhanced extrusion of drugs mediated by efflux pump proteins belonging to either the ABC (ATP-binding cassette) superfamily or MFS (major facilitator superfamily). These drug-efflux pump proteins are localized on the plasma membrane, and the milieu therein affects their proper functioning. Several recent studies demonstrate that fluctuations in membrane lipid composition affect the localization and proper functioning of the MDR efflux pump proteins. Interestingly, the efflux pumps of the ABC superfamily are particularly susceptible to imbalances in membrane-raft lipid constituents. This review focuses on the importance of the membrane environment in functioning of the drug-efflux pumps and explores a correlation between MDR and membrane lipid homoeostasis.
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Review Article|
September 01 2008
Membrane homoeostasis and multidrug resistance in yeast
Sneh Lata Panwar;
Sneh Lata Panwar
*Yeast Molecular Genetics Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
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Ritu Pasrija;
Ritu Pasrija
1
†Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
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Rajendra Prasad
Rajendra Prasad
2
†Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
2To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
June 12 2008
Revision Received:
July 16 2008
Accepted:
July 21 2008
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biosci Rep (2008) 28 (4): 217–228.
Article history
Received:
June 12 2008
Revision Received:
July 16 2008
Accepted:
July 21 2008
Citation
Sneh Lata Panwar, Ritu Pasrija, Rajendra Prasad; Membrane homoeostasis and multidrug resistance in yeast. Biosci Rep 1 August 2008; 28 (4): 217–228. doi: https://doi.org/10.1042/BSR20080071
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