Recent reports demonstrate that the RIC-3 (resistant to inhibitors of cholinesterase-3) protein is important for the maturation of nAChRs (nicotinic acetylcholine receptors). In the present study RIC-3e, a novel variant of RIC-3, is described. This variant contains a deletion of exons 4 and 5 of RIC-3, resulting in a protein product lacking a conserved coiled-coil domain. Like RIC-3, the new variant is predominantly, but not exclusively, expressed in the brain. The analysis of expression of variant RIC-3 mRNA and of α7-nAChR mRNA in a set of human tissues shows a similar profile. The RIC-3e protein is functionally active and enables surface expression of mature α7-nAChRs in cell lines not otherwise permissive for the expression of this receptor.
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Research Article|
October 07 2008
Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors
Tamara Seredenina;
Tamara Seredenina
1Siena Biotech S.p.A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
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Teresa Ferraro;
Teresa Ferraro
1Siena Biotech S.p.A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
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Georg C. Terstappen;
Georg C. Terstappen
1Siena Biotech S.p.A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
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Andrea Caricasole;
Andrea Caricasole
1Siena Biotech S.p.A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
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Renza Roncarati
Renza Roncarati
1
1Siena Biotech S.p.A, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy
1To whom correspondence should be addressed (email [email protected]).
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Publisher: Portland Press Ltd
Received:
June 10 2008
Revision Received:
August 05 2008
Accepted:
August 11 2008
Accepted Manuscript online:
August 11 2008
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biosci Rep (2008) 28 (6): 299–306.
Article history
Received:
June 10 2008
Revision Received:
August 05 2008
Accepted:
August 11 2008
Accepted Manuscript online:
August 11 2008
Citation
Tamara Seredenina, Teresa Ferraro, Georg C. Terstappen, Andrea Caricasole, Renza Roncarati; Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors. Biosci Rep 1 December 2008; 28 (6): 299–306. doi: https://doi.org/10.1042/BSR20080055
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