Leupeptin, a proteinase inhibitor obtained from culture filtrates of Streptomyces sp., has been proposed as a valuable agent for the restriction of proteolysis in vivo. We have previously shown that mammalian tissues possess an enzymic system that is capable of inactivating leupeptin (Beynon R39 Brown CP & Butler PEr 1981, Acta. Biol. Med. Germ. 40, 1539–1546). This paper demonstrates the ubiquitous distribution of the inactivating system throughout mammalian tissues and provides evidence for the location of the enzyme(s) in the soluble fraction of the cell.

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