Special codes are embedded in the primary sequence of newly synthesized proteins to determine their final destination. Protein translocation across biological membranes requires co-operation between the targeting and translocation machineries. A conserved membrane channel, the Sec61/SecY complex, mediates protein translocation across or integration into the endoplasmic reticulum membrane in eukaryotes and the plasma membrane in prokaryotes. A combination of recent biochemical and structural data provides novel insights into the mechanism of how the channel allows polypeptide movement into the exoplasmic space and the lipid bilayer.
Review Article| February 17 2010
Protein translocation through the Sec61/SecY channel
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Zhiliang Cheng; Protein translocation through the Sec61/SecY channel. Biosci Rep 1 June 2010; 30 (3): 201–207. doi: https://doi.org/10.1042/BSR20090158
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