It has long been thought that PTPs (protein tyrosine phosphatases) normally function as tumour suppressors. Recent high-throughput mutational analysis identified loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes. PTPRT (protein tyrosine phosphatase receptor-T), a member of the family of type IIB receptor-like PTPs, is the most frequently mutated PTP among them. Consistent with the notion that PTPRT is a tumour suppressor, PTPRT knockout mice are hypersensitive to AOM (azoxymethane)-induced colon cancer. The present review focuses on the physiological and pathological functions of PTPRT as well as the cellular pathways regulated by this phosphatase.
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Review Article| April 21 2011
Tumour suppressor function of protein tyrosine phosphatase receptor-T
Zhenghe Wang 1
1Department of Genetics and Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, U.S.A.
1To whom correspondence should be addressed (email email@example.com).
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Anthony Scott, Zhenghe Wang; Tumour suppressor function of protein tyrosine phosphatase receptor-T. Biosci Rep 1 October 2011; 31 (5): 303–307. doi: https://doi.org/10.1042/BSR20100134
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