In perfused rat liver a decrease of cytosol pH, determined with pH-sensitive microelectrodes7 from 7.2 to 6.85 is associated with a 50% fall in ureogenesis from ammonium chloride. In isolated rat hepatocytes the fall in ureogenesis due to acidosis is associated with decrease in the mitochondrial and cytosolic concentration of citrulline. Limitation of carbamoyl phosphate synthesis and thus citrulline supply could be responsible for the inhibition of ureogenesis observed.
The mechanism of inhibition of ureogenesis by acidosis
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J. P. Monson, R. M. Henderson, J. A. Smith, R. A. Iles, M. Faus-Dader, N. D. Carter, R. Heath, H. Metcalfe, R. D. Cohen; The mechanism of inhibition of ureogenesis by acidosis. Biosci Rep 1 October 1984; 4 (10): 819–825. doi: https://doi.org/10.1007/BF01138163
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