The parathyroid hormone (PTH) release and cytosolic Ca2+ activity were determined in normal bovine parathyroid cells and parathyroid cells obtained from patients with hyperparathyroidism (HPT). There was a sigmoid relation between the cytosolic Ca2+ activity and the extracellular calcium concentration between 0.5 and 6.0 mmol/l. The PTH release was inhibited in parallel with the rise in the cytosolic Ca2+ activity. Both the hormone release and the cytosolic Ca2+ activity were lower in cells from human adenomas and hyperplastic glands∼ and in comparison with the bovine preparations these ceils had higher set points for the cytosolic Ca2+ activity and PTH release. There was a close correlation between the individual set points for the cytosolic Ca2+ activity and PTH release in a material containing both normal and pathological cells. The results indicate that the abnormal PTH release characteristic of HPT is due to a defective regulation of the cytosolic Ca2+ activity.
Skip Nav Destination
Article navigation
Research Article|
November 01 1984
Defective regulation of the cytosolic Ca2+ activity in parathyroid cells from patients with hyperparathyroidism
Rolf Larsson;
Rolf Larsson
1Departments of Medical Cell Biology, Surgery, Internal Medicine, and Clinical Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden
Search for other works by this author on:
Chris Wallfelt;
Chris Wallfelt
1Departments of Medical Cell Biology, Surgery, Internal Medicine, and Clinical Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden
Search for other works by this author on:
Håkan Abrahamsson;
Håkan Abrahamsson
1Departments of Medical Cell Biology, Surgery, Internal Medicine, and Clinical Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden
Search for other works by this author on:
Erik Gylfe;
Erik Gylfe
1Departments of Medical Cell Biology, Surgery, Internal Medicine, and Clinical Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden
Search for other works by this author on:
Sverker Ljunghall;
Sverker Ljunghall
1Departments of Medical Cell Biology, Surgery, Internal Medicine, and Clinical Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden
Search for other works by this author on:
Jonas Rastad;
Jonas Rastad
1Departments of Medical Cell Biology, Surgery, Internal Medicine, and Clinical Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden
Search for other works by this author on:
Patrik Rorsman;
Patrik Rorsman
1Departments of Medical Cell Biology, Surgery, Internal Medicine, and Clinical Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden
Search for other works by this author on:
Leif Wide;
Leif Wide
1Departments of Medical Cell Biology, Surgery, Internal Medicine, and Clinical Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden
Search for other works by this author on:
Göran Åkerström
Göran Åkerström
1Departments of Medical Cell Biology, Surgery, Internal Medicine, and Clinical Chemistry, University of Uppsala, S-751 23 Uppsala, Sweden
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 24 1984
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1984 The Biochemical Society
1984
Biosci Rep (1984) 4 (11): 909–915.
Article history
Received:
September 24 1984
Citation
Rolf Larsson, Chris Wallfelt, Håkan Abrahamsson, Erik Gylfe, Sverker Ljunghall, Jonas Rastad, Patrik Rorsman, Leif Wide, Göran Åkerström; Defective regulation of the cytosolic Ca2+ activity in parathyroid cells from patients with hyperparathyroidism. Biosci Rep 1 November 1984; 4 (11): 909–915. doi: https://doi.org/10.1007/BF01116888
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |