Three myoid-cell clones were established from the thymuses of two Wistar rats; one thymus yielded two clones, RBISA and R615B2, and the other yielded one clone, R613Ad. The three clones were divided into two subtypes. Both subtypes were able to form myofibrils, expressed AChR on their cell-surface membrane, and contained myofibrillar ATPase characteristic of und ifferentiated type-2C fibers, but they differed from each other in morphology, expression of Thy 1 antigen, spontaneous contractility, and qualitative accumulation of AChR. Immunolocalization studies using antisera against the respective cell subtypes also indicated regional differences in their cellular origin. These results show that the thymus contains heterogenous myoid-cell precursors.
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Research Article|
November 01 1984
Clonal heterogeneity of thymic muscle-cell precursors
Isao Kamo;
Isao Kamo
1National Center for Nervous, Mental and Muscular Disorders, 2620 Ogawahigashi Kodaira 187, Japan
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Ikuya Nonaka;
Ikuya Nonaka
1National Center for Nervous, Mental and Muscular Disorders, 2620 Ogawahigashi Kodaira 187, Japan
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Shoei Furukawa;
Shoei Furukawa
1National Center for Nervous, Mental and Muscular Disorders, 2620 Ogawahigashi Kodaira 187, Japan
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Eijiro Satoyoshi
Eijiro Satoyoshi
1National Center for Nervous, Mental and Muscular Disorders, 2620 Ogawahigashi Kodaira 187, Japan
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Publisher: Portland Press Ltd
Received:
September 28 1984
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1984 The Biochemical Society
1984
Biosci Rep (1984) 4 (11): 925–932.
Article history
Received:
September 28 1984
Citation
Isao Kamo, Ikuya Nonaka, Shoei Furukawa, Eijiro Satoyoshi; Clonal heterogeneity of thymic muscle-cell precursors. Biosci Rep 1 November 1984; 4 (11): 925–932. doi: https://doi.org/10.1007/BF01116890
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