Oxidation of pyruvate, α-ketoglutarate, palmitoylcarnitine, succinate, and ferrocytochrome c by interscapular-brown-adipose-tissue (BAT) mitochondria of untrained and trained rats were measured at rest and alter running to exhaustion. At rest, BAT mitochondria from trained rats showed significantly lower activities (<50%) for the oxidation of all the substrates. In untrained rats the activities of the enzymes for the oxidation of all the substrates except pyruvate and succinate were lower at exhaustion compared to the resting state when expressed on a per-gram-fresh-Weight basis. In trained rats all of the enzyme activities increased as a result of exhaustive exercise. These differences between the two groups of rats in the post-exercise changes in oxidative capacities suggest that following an initial adaptation, resulting in a large decrease in mitochondrial oxidative activity, training protects the residual oxidative pathways against exercise-induced inactivation. These data show that unlike exposure to cold, or overfeeding, a physiological stimulus such as exercise reduces the oxidative capacity of BAT, and therefore may reduce the thermogenic activity of the tissue in endurance-trained rats as has been addressed in the scientific literature.
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Research Article|
November 01 1984
Effects of training and exhaustive exercise on the mitochondrial oxidative capacity of brown adipose tissue
K. Gohil;
K. Gohil
1Membrane Bioenergetics Group, Department of Physiology & Anatomy, University of California, Berkeley, California 94720, USA
2Exercise Physiology Laboratory, Department of Physical Education, University of California, Berkeley, California 94720, USA
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S. Henderson;
S. Henderson
1Membrane Bioenergetics Group, Department of Physiology & Anatomy, University of California, Berkeley, California 94720, USA
2Exercise Physiology Laboratory, Department of Physical Education, University of California, Berkeley, California 94720, USA
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S. E. Terblanche;
S. E. Terblanche
1Membrane Bioenergetics Group, Department of Physiology & Anatomy, University of California, Berkeley, California 94720, USA
2Exercise Physiology Laboratory, Department of Physical Education, University of California, Berkeley, California 94720, USA
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G. A. Brooks;
G. A. Brooks
1Membrane Bioenergetics Group, Department of Physiology & Anatomy, University of California, Berkeley, California 94720, USA
2Exercise Physiology Laboratory, Department of Physical Education, University of California, Berkeley, California 94720, USA
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L. Packer
L. Packer
1Membrane Bioenergetics Group, Department of Physiology & Anatomy, University of California, Berkeley, California 94720, USA
2Exercise Physiology Laboratory, Department of Physical Education, University of California, Berkeley, California 94720, USA
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Publisher: Portland Press Ltd
Received:
October 30 1984
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1984 The Biochemical Society
1984
Biosci Rep (1984) 4 (11): 987–993.
Article history
Received:
October 30 1984
Citation
K. Gohil, S. Henderson, S. E. Terblanche, G. A. Brooks, L. Packer; Effects of training and exhaustive exercise on the mitochondrial oxidative capacity of brown adipose tissue. Biosci Rep 1 November 1984; 4 (11): 987–993. doi: https://doi.org/10.1007/BF01116898
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